WebMar 1, 2015 · Total syntheses of (+)-dictyoceratin-C (1) and (+)-dictyoceratin-A (smenospondiol) (2), hypoxia-selective growth inhibitors isolated from marine sponge, were executed. The absolute stereochemistry of the each compound was determined through the enantioselective total syntheses of them. It revealed t … WebJul 15, 2014 · In the course of our search for hypoxia-selective growth inhibitors against cancer cells, a sesquiterpene phenol, dictyoceratin-C (1), was isolated from the Indonesian marine sponge of Dactylospongia elegans under the guidance of the constructed bioassay.Dictyoceratin-C (1) inhibited proliferation of human prostate cancer DU145 …

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Webdictyoceratin-C (1) &HtH Dictyoceratin-C (1)lùN I 30 o) dictyoceratin-A (2)ñÈN 1 (Figure DU 145 100 o MeO 17 OH 18 R = H dictyoceratin-C (1) OH dictyoceratin-A (2) Figure 1 o hypoxia OX i a 80 60 40 20 10 30 concentration of 1 (PM) Structural optimization and mechanistic analysis of the anti-proliferative WebThe marine spongean sesquiterpene phenols dictyoceratin-A (1) and -C (2) have been shown to induce hypoxia-selective growth inhibition in cultured cancer cells and exhibit in … crgt inc

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Webdictyoceratin A C23H32O4 CID 9885835 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … WebDec 16, 2015 · Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma … WebDec 16, 2015 · Abstract: Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure–activity relationship of the natural compounds 1 and 2 isolated from a marine … buddy mix recipe