WebNature Cancer The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer – Nature Cancer - Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal stability arising from … WebDec 1, 2024 · CIP2A, a 90 kDa oncoprotein, was originally named KIAA1524 or p90 which is encoded by KIAA1524 gene located on 3q13.13 in human [11].Sequence analysis of KIAA1524 demonstrates insignificant homology to any protein with known function, but the protein has several protein–protein interaction domains [12].Moreover, the studies …
Daniel Durocher on Twitter: "CIP2A encodes a fascinating protein …
WebThe Durocher Lab researches how normal cells become cancerous by elucidating how genome integrity is maintained. We use genetic, biochemical, functional genomic and proteomic approaches in yeast and … WebFeb 28, 2024 · Fig. 1: CIP2A interacts with B56α via its N-terminal head domain. A In red are indicated CIP2A (1-560) residues identified in inter-molecular cross-links to B56α using DSS and DMTMM... riverside 5 family restaurant
The role of CIP2A in cancer: A review and update - ScienceDirect
WebDurocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal stability arising from accumulated DNA lesions in BRCA-mutated tumor cells.BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination … WebMar 26, 2024 · This study is the first to describe a pathogenic CIP2A mutation in humans, which might disrupt neuronal development via enhancing mTOR and c-Myc protein expressions, shedding light in mechanisms of Dandy-Walker variant pathogenesis. biomarker for metastasis and prognosis in clear cell renal cell carcinoma WebFeb 8, 2024 · CIP2A is cytoplasmic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. In … smoked chicken finish temp