WebAug 30, 2024 · At select sites in Europe and the US, an open-label extension (OLE) study was subsequently conducted in 6634 patients who completed the parent FOURIER trial. All FOURIER-OLE patients self-injected open-label evolocumab (also the patients who were originally allocated to placebo in the parent study), with the choice of 140 mg biweekly or … WebApr 22, 2024 · この試験では、当初最大耐用量のスタチン内服下の患者が対象となっていたが、試験途中でプロトコールの変更があり、アトルバスタチン20mg以上の至適薬物治 …
Association Between Achieved Low-Density Lipoprotein …
WebAug 30, 2024 · 图1:fourier研究与fourier-ole研究不良事件发生率相似. 与fourier研究不同,在fourier-ole研究中,与曾为安慰剂组患者相比,曾为fourier研究中依洛尤单抗组患者的心血管死亡、心肌梗死、卒中、因不稳定型心绞痛住院或冠状动脉血运重建等主要不良事件发生率更低( p =0.008),心血管死亡事件风险下降23%。 WebAug 29, 2024 · The parent FOURIER trial was a randomized, double-blind, placebo-controlled, multinational clinical trial. 4 At study conclusion, patients at sites throughout the United States and Europe were considered for participation in the open-label long … goshen temple sda church brooklyn
Long-Term Evolocumab in Patients With Established …
WebApr 27, 2024 · The FOURIER-OLE (Further cardiovascular OUtcomes Research with PCSK9 Inhibition in Subjects with Elevated – Risk-Open Label Extension) studies were composed of study 20130295 (NCT02867813) with ... WebAug 19, 2024 · Findings from the trial, known as FOURIER open-label extension (OLE), sponsored by Amgen, were presented at a Hot Line session at ESC Congress 2024 by the study’s principal investigator Michelle O’Donoghue, MD, MPH, a senior investigator of the TIMI Study Group in the Division of Cardiovascular Medicine. More than 6,000 … chief architect scissor truss