WebFeb 3, 2024 · The headache is piercing or throbbing and moves from the base of the skull toward the sides and front of the head. 13 Spontaneous intracranial hypotension occurs when there is low spinal fluid pressure in the brain. It causes a severe headache that is typically located in the back of the head. WebAcetaminophen, aspirin and caffeine, when taken as directed, provide clinically proven headache relief. Excedrin is a combination of these ingredients: two pain relievers, plus an amplifier to enhance the analgesic effect. Acetaminophen, also known as paracetamol, should not be taken with other medicines that also contain acetaminophen.
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