Web3 de jun. de 2024 · Agrawal, A. et al. Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the … Web1 de jun. de 2024 · HIF-1 and HIF-2, the most extensively studied HIF transcription factors, facilitate oxygen delivery and cellular adaptation to hypoxia by regulating a wide spectrum of hypoxia responses such as angiogenesis, anaerobic glucose metabolism, mitochondrial biogenesis, and others. 18 The list of genes that are directly HIF-regulated is large and …
HIFs, angiogenesis, and metabolism: elusive enemies in breast …
Web15 de ago. de 2024 · A decrease in HIF-1 activity is crucial during perinatal remodeling when the heart switches from anaerobic to aerobic metabolism. In the adult heart, HIF-1 protects against hypoxia, although its deletion in cardiomyocytes affects heart function even under normoxic conditions. Diabetes impairs HIF-1 activation and thus, compromises HIF-1 ... WebHIF-α TRENDS in Endocrinology & Metabolism Figure 1. Regulation of HIF protein and the role of HIFs in various tissue types. (a) Under normoxic conditions HIF a subunits are … cystathionine gamma-lyase 缩写
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism …
Web16 de abr. de 2024 · Since myocardial metabolism is strictly dependent on hormonal status as well as substrate milieu, the above mentioned disturbances may affect energy generation status in the heart. ... HIF-1, metabolism, and diabetes in the embryonic and adult heart. Front. Endocrinol. 9: ... Web14 de mai. de 2024 · Author summary The impact of host cell metabolism on pathogen growth or restriction represent an emerging field in immunology and shed light on the intricate network of signaling pathways during immune cells response. Here, we dissected a distinct mechanism by which STING regulates macrophage metabolic reprogramming … Web11 de abr. de 2024 · Third, although all HIF-PHIs are potent inhibitors of PHD1, PHD2, and PHD3 and stabilize HIF-α(66), they display differences in their pharmacokinetic and … cystathionine gamma-synthase 1