Phospho-acss2
WebMay 31, 2024 · A decrease in ACSS2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of neuronal genes. In adult mice, attenuation of hippocampal ACSS2 expression ... WebMar 1, 2024 · The standard compounds, including pyruvate, lactate, alanine, acetate, succinate, glucose, palmitate, glycine, glutamate, isoleucine, valine, leucine, and …
Phospho-acss2
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WebAutoantigen. PLA2R is a type I transmembrane receptor and is one of four members of the mammalian mannose receptor family. It is a 185-kDa protein expressed on, and confined … WebJun 7, 2024 · The authors monitored ACSS2 subcellular localization in human glioblastoma cells and observed that cytosolic ACSS2 translocated into the nucleus when the cells …
Web3.1.3 Phospholipase A2 Inhibition. Phospholipase A2 (PLA2), which cleaves phospholipids producing lysophospholipids and free fatty acids, was originally identified as an … WebFeb 6, 2024 · ACSS2, endogenous ACSS2 protein; His-ACSS2, reintroduced exogenous ACSS2 protein; L, long exposure; S, short exposure. (C) HCMV growth was rescued by the reintroduction of ACSS2-resistant guide RNA. Two days after reintroduction of His-ACSS2-R, cells were serum-starved overnight and were infected with HCMV at an MOI of 3. Viruses …
WebNutritional stresses, which restrict acetyl-CoA production from glucose or acetate uptake, result in AMPK-mediated phosphorylation and nuclear translocation of ACSS2. ACSS2 binds to TFEB, translocates to lysosomal and autophagosomal gene promoter regions, and incorporates acetate from histone acetylation turnover to locally produce acetyl-CoA for … WebIn the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from …
WebJun 1, 2024 · ACSS2 is phosphorylated at Ser659 by AMPK and then forms a translocation complex with Importin α5 to translocate into the nucleus. This process interacts with TFEB, resulting in upregulated...
WebNational Center for Biotechnology Information highlightcrafts.com/shop/downloadsWebMar 1, 2024 · VY-3-135 is a potent, stable ACSS2 inhibitor with good bioavailability. (A) Schematic of the forward reaction catalyzed by ACSS2. (B-C) Chemical structures of VY-3-249 and VY-3-135 and IC50 determinations for inhibitors against ACSS1 (blue squares) and ACSS2 (red circles). Data points represent mean (filled shapes) and replicates (empty … small pet for childWebImportantly, we show that ACSS2 Ser-267 phosphorylation regulates its stability by reducing polyubiquitination and degradation. ACSS2 Ser-267 is critical for OGT-mediated GBM … small pet grooming suppliesWebJul 21, 2024 · To silence Acly and Acss2, cells were infected with 50 MOI shACLY/shACSS2 adenovectors (Vector BioLabs). To perform co-silencing of Hdac3 and Acly/Acss2, cells at the induction of differentiation ... small pet gates indoorWebSep 18, 2024 · Acss2 Deletion Protects Against Lipid Deposition and Obesity. To gain insight into the normal physiological function of ACSS2, we compared Acss2 -null mice with … highlighted as an editor\u0027s pickWebNov 12, 2024 · ACSS2 is the only known enzyme that can recycle acetate derived from deacetylation reactions in the cytoplasm and nucleus of cells, including both protein and metabolite deacetylation reactions. As such, ACSS2 can recycle acetate derived from histone deacetylase reactions as well as protein deacetylation reactions mediated by … highlighte.comWebPhospho (6) Supplier US Biological (50) Biorbyt (48) LSBio (39) Aviva Systems Biology (12) antibodies-online (12) ABclonal (2) Abbexa (9) Abbkine (1) Abcam (5) Abgent (2) ... Anti-ACSS2 antibody produced in rabbit. HPA004141 is a primary antibody from MilliporeSigma. 3 Citations Host: Rabbit Clonality: Polyclonal Validations: None Available small pet halloween costumes