Webtarget protein. Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb detects endogenous levels of p46 and p54 SAPK/JNK only when phosphorylated at Thr183 and … Phospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Human eIF2alpha residue Ser52 historically has been referenced as Ser51. Species Reactivity: Human, Mouse, Rat, Monkey, D. melanogaster
PI3K signaling mediates diverse regulation of ATF4 ... - Springer
WebMay 3, 2024 · Stress-responsive kinases phosphorylate eIF2α at conserved Ser51, transforming eIF2 from substrate into a competitive GEF inhibitor. ... yet eIF2Bα deletion impairs phospho-inhibition of eIF2B, consistent with the subunit’s role in binding eIF2α-P. Point mutations with identical phenotypes cluster at the interface between eIF2Bα and ... WebJan 1, 2024 · Primary monoclonal antibodies (clone name; catalog number) used were phospho-eIF2α Ser51 (D9G8; 3398), eIF2α (D7D3; 5324), phospho-p70 S6 kinase Thr389 (1A5; 9206), p70 S6 kinase (49D7; 2708), and α-tubulin (11H10; 2125) were obtained from Cell Signaling Technologies (Danvers, MA). shuffle dance songs playlist
Structural basis of eIF2B-catalyzed nucleotide exchange and ...
WebAug 4, 2024 · Cell Signaling Technology's Phospho-eIF2alpha (Ser51) (D9G8) XP ® Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-eIF2alpha (Ser51) (D9G8) XP ® … WebAntibody Duet for studying EIF2S1/eIF2-alpha/EIF2S1/eIF2-alpha (Ser52) phosphate in the research area. WebThe phosphorylation of eIF2α at Ser51 is well known to prevent a step in the initiation of translation and thereby block global protein synthesis [45,46]. eIF2α was phosphorylated in response to various cellular stresses [53,54]. We found that isopanduratin A up-regulated the level of phospho-eIF2α (Ser 51) within 1 h. the other side of earth